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Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis
The role of autophagy and its relationship with apoptosis in Alzheimer disease (AD) pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely digested substrates, amyloid-β (Aβ) peptide accumulation in vacuoles and cell death. Aβ, in turn, has been found to affect a...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Landes Bioscience
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4198366/ https://ncbi.nlm.nih.gov/pubmed/25136804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.30001 |
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