Nonphosphorylated tau slows down Aβ(1–42) aggregation, binds to Aβ(1–42) oligomers, and reduces Aβ(1–42) toxicity

The formation of neurofibrillary tangles and amyloid plaques accompanies the progression of Alzheimer's disease. Tangles are made of fibrillar aggregates formed by the microtubule-associated protein tau, whereas plaques comprise fibrillar forms of amyloid-beta (Aβ). Both form toxic oligomers du...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Beeg, Marten, Battocchio, Elisabetta, De Luigi, Ada, Colombo, Laura, Natale, Carmina, Cagnotto, Alfredo, Corbelli, Alessandro, Fiordaliso, Fabio, Diomede, Luisa, Salmona, Mario, Gobbi, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113980/
https://ncbi.nlm.nih.gov/pubmed/33865852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100664
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