Nonphosphorylated tau slows down Aβ(1–42) aggregation, binds to Aβ(1–42) oligomers, and reduces Aβ(1–42) toxicity

The formation of neurofibrillary tangles and amyloid plaques accompanies the progression of Alzheimer's disease. Tangles are made of fibrillar aggregates formed by the microtubule-associated protein tau, whereas plaques comprise fibrillar forms of amyloid-beta (Aβ). Both form toxic oligomers du...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Beeg, Marten, Battocchio, Elisabetta, De Luigi, Ada, Colombo, Laura, Natale, Carmina, Cagnotto, Alfredo, Corbelli, Alessandro, Fiordaliso, Fabio, Diomede, Luisa, Salmona, Mario, Gobbi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113980/
https://ncbi.nlm.nih.gov/pubmed/33865852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100664
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