The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers

15B3 is a monoclonal IgM antibody that selectively detects pathological aggregates of the prion protein (PrP). We report the unexpected finding that 15B3 also recognizes oligomeric but not monomeric forms of amyloid-β (Aβ)(42), an aggregating peptide implicated in the pathogenesis of Alzheimer’s dis...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Alzheimers Dis
Huvudupphovsmän: Stravalaci, Matteo, Tapella, Laura, Beeg, Marten, Rossi, Alessandro, Joshi, Pooja, Pizzi, Erika, Mazzanti, Michele, Balducci, Claudia, Forloni, Gianluigi, Biasini, Emiliano, Salmona, Mario, Diomede, Luisa, Chiesa, Roberto, Gobbi, Marco
Materialtyp: Artigo
Språk:Inglês
Publicerad: IOS Press 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5044783/
https://ncbi.nlm.nih.gov/pubmed/27392850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-150882
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