Specific Recognition of Biologically Active Amyloid-β Oligomers by a New Surface Plasmon Resonance-based Immunoassay and an in Vivo Assay in Caenorhabditis elegans

Soluble oligomers of the amyloid-β (Aβ) peptide play a key role in the pathogenesis of Alzheimer's disease, but their elusive nature makes their detection challenging. Here we describe a novel immunoassay based on surface plasmon resonance (SPR) that specifically recognizes biologically active...

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Detalhes bibliográficos
Main Authors: Stravalaci, Matteo, Bastone, Antonio, Beeg, Marten, Cagnotto, Alfredo, Colombo, Laura, Di Fede, Giuseppe, Tagliavini, Fabrizio, Cantù, Laura, Del Favero, Elena, Mazzanti, Michele, Chiesa, Roberto, Salmona, Mario, Diomede, Luisa, Gobbi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431664/
https://ncbi.nlm.nih.gov/pubmed/22736768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334979
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