Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity()

Although Alzheimer's disease (AD) is usually sporadic, in a small proportion of cases it is familial and can be linked to mutations in β-amyloid precursor protein (APP). Unlike the other genetic defects, the mutation [alanine-673→valine-673] (A673V) causes the disease only in the homozygous con...

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Detalhes bibliográficos
Main Authors: Diomede, Luisa, Di Fede, Giuseppe, Romeo, Margherita, Bagnati, Renzo, Ghidoni, Roberta, Fiordaliso, Fabio, Salio, Monica, Rossi, Alessandro, Catania, Marcella, Paterlini, Anna, Benussi, Luisa, Bastone, Antonio, Stravalaci, Matteo, Gobbi, Marco, Tagliavini, Fabrizio, Salmona, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068289/
https://ncbi.nlm.nih.gov/pubmed/24184799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.10.024
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