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Structure, Function and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

We report the first structure of heptaprenyl diphosphate synthase from Staphylococcus aureus (SaHepPPS), together with an investigation of its mechanism of action, and inhibition. The protein is involved in the formation of menaquinone, a key electron transporter in many bacteria, including pathogen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemMedChem
Prif Awduron: Desai, Janish, Liu, Yi-Liang, Wei, Hongli, Liu, Weidong, Ko, Tzu-Ping, Guo, Rey-Ting, Oldfield, Eric
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012948/
https://ncbi.nlm.nih.gov/pubmed/27457559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600311
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