Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase, induces mitochondrial injury and apoptosis in human leukemia cells through the mitochondrial translocation of cofilin. Only dephosphorylated cofilin could translocate to mitochondria during cerulenin-ind...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Zhang, Yanhao, Fu, Ruoqiu, Liu, Yanxia, Li, Jing, Zhang, Hongwei, Hu, Xiaoye, Chen, Yibiao, Liu, Xin, Li, Yunong, Li, Ping, Liu, Ehu, Gao, Ning
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991482/
https://ncbi.nlm.nih.gov/pubmed/26967395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7994
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak