Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase, induces mitochondrial injury and apoptosis in human leukemia cells through the mitochondrial translocation of cofilin. Only dephosphorylated cofilin could translocate to mitochondria during cerulenin-ind...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Zhang, Yanhao, Fu, Ruoqiu, Liu, Yanxia, Li, Jing, Zhang, Hongwei, Hu, Xiaoye, Chen, Yibiao, Liu, Xin, Li, Yunong, Li, Ping, Liu, Ehu, Gao, Ning
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991482/
https://ncbi.nlm.nih.gov/pubmed/26967395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7994
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