Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway

In this study, we determined that cerulenin, a natural product inhibitor of fatty acid synthase, induces mitochondrial injury and apoptosis in human leukemia cells through the mitochondrial translocation of cofilin. Only dephosphorylated cofilin could translocate to mitochondria during cerulenin-ind...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhang, Yanhao, Fu, Ruoqiu, Liu, Yanxia, Li, Jing, Zhang, Hongwei, Hu, Xiaoye, Chen, Yibiao, Liu, Xin, Li, Yunong, Li, Ping, Liu, Ehu, Gao, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991482/
https://ncbi.nlm.nih.gov/pubmed/26967395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7994
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