The cyclohexene derivative MC-3129 exhibits antileukemic activity via RhoA/ROCK1/PTEN/PI3K/Akt pathway-mediated mitochondrial translocation of cofilin

The effects of MC-3129, a synthetic cyclohexene derivative, on cell viability and apoptosis have been investigated in human leukemia cells. Exposure of leukemia cells to MC-3129 led to the inhibition of cell viability and induction of apoptosis through the dephosphorylation and mitochondrial translo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Zheng, Yi, Ouyang, Qin, Fu, Ruoqiu, Liu, Lei, Zhang, Hongwei, Hu, Xiaoye, Liu, Yanxia, Chen, Yingchun, Gao, Ning
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974298/
https://ncbi.nlm.nih.gov/pubmed/29844397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0689-4
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