The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlle...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Miller-Fleming, Tyne W, Petersen, Sarah C, Manning, Laura, Matthewman, Cristina, Gornet, Megan, Beers, Allison, Hori, Sayaka, Mitani, Shohei, Bianchi, Laura, Richmond, Janet, Miller, David M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980115/
https://ncbi.nlm.nih.gov/pubmed/27403890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14599
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