The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlle...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Miller-Fleming, Tyne W, Petersen, Sarah C, Manning, Laura, Matthewman, Cristina, Gornet, Megan, Beers, Allison, Hori, Sayaka, Mitani, Shohei, Bianchi, Laura, Richmond, Janet, Miller, David M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980115/
https://ncbi.nlm.nih.gov/pubmed/27403890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.14599
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