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Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations
Ion channels of the DEG/ENaC family can induce neurodegeneration under conditions in which they become hyperactivated. The Caenorhabditis elegans DEG/ENaC channel MEC-4(d) encodes a mutant channel with a substitution in the pore domain that causes swelling and death of the six touch neurons in which...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3727304/ https://ncbi.nlm.nih.gov/pubmed/23898007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310974 |
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