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Spliceosomal DEAH-box ATPases remodel pre-mRNA to activate alternative splice sites

During pre-mRNA splicing, a central step in the expression and regulation of eukaryotic genes, the spliceosome selects splice sites for intron excision and exon ligation. In doing so, the spliceosome must distinguish optimal from suboptimal splice sites. At the catalytic stage of splicing, suboptima...

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Publicat a:Cell
Autors principals: Semlow, Daniel R., Blanco, Mario R., Walter, Nils G., Staley, Jonathan P.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979991/
https://ncbi.nlm.nih.gov/pubmed/26919433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.025
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