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The DEAH-box ATPases Prp16 and Prp43 cooperate to proofread 5′ splice site cleavage during pre-mRNA splicing

To investigate the mechanism of fidelity in pre-mRNA splicing, we developed an in vitro assay sensitive to proofreading of 5′ splice site cleavage. We inactivated spliceosomes by disrupting a critical metal-ligand interaction at the catalytic center and discovered that when the DEAH-box ATPase Prp16...

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Xehetasun bibliografikoak
Egile Nagusiak: Koodathingal, Prakash, Novak, Thaddeus, Piccirilli, Joseph A., Staley, Jonathan P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722364/
https://ncbi.nlm.nih.gov/pubmed/20705241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.07.014
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