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Spliceosome discards intermediates via the DEAH box ATPase Prp43p

To promote fidelity in nuclear pre-mRNA splicing, the spliceosome rejects and discards suboptimal substrates that have engaged the spliceosome. Whereas DExD/H box ATPases have been implicated in rejecting suboptimal substrates, the mechanism for discarding suboptimal substrates has remained obscure....

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Detalles Bibliográficos
Autores principales: Mayas, Rabiah M., Maita, Hiroshi, Semlow, Daniel R., Staley, Jonathan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890470/
https://ncbi.nlm.nih.gov/pubmed/20463285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906022107
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