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Spliceosomal DEAH-box ATPases remodel pre-mRNA to activate alternative splice sites

During pre-mRNA splicing, a central step in the expression and regulation of eukaryotic genes, the spliceosome selects splice sites for intron excision and exon ligation. In doing so, the spliceosome must distinguish optimal from suboptimal splice sites. At the catalytic stage of splicing, suboptima...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Semlow, Daniel R., Blanco, Mario R., Walter, Nils G., Staley, Jonathan P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979991/
https://ncbi.nlm.nih.gov/pubmed/26919433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.025
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