Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage

OBJECTIVES: To analyze the methylome of normal and osteoarthritis (OA) knee articular cartilage and determine the role of DNA methylation in the regulation of gene expression in vitro. METHODS: DNA was isolated from human normal (N=11) and OA (N=12) knee articular cartilage and analyzed by an Infini...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Alvarez-Garcia, Oscar, Fisch, Kathleen M., Wineinger, Nathan E., Akagi, Ryuichiro, Saito, Masahiko, Sasho, Takahisa, Su, Andrew I., Lotz, Martin K
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4963260/
https://ncbi.nlm.nih.gov/pubmed/26881698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39643
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