FoxO transcription factors influence cartilage maturation, homeostasis and osteoarthritis pathogenesis by modulating autophagy and proteoglycan 4

Aging is a main risk factor for osteoarthritis (OA). FoxO transcription factors protect against cellular and organismal aging and FoxO expression in cartilage is reduced with aging and in OA. To investigate FoxO in cartilage function, single and triple FoxO1/3/4 floxed mice were crossed with Col2-Cr...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Matsuzaki, Tokio, Alvarez-Garcia, Oscar, Mokuda, Sho, Nagira, Keita, Olmer, Merissa, Gamini, Ramya, Miyata, Kohei, Akasaki, Yukio, Su, Andrew I., Asahara, Hiroshi, Lotz, Martin K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204214/
https://ncbi.nlm.nih.gov/pubmed/29444976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan0746
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