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FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration

Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging are unknown. The aim of this study was to inve...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Alvarez‐Garcia, Oscar, Matsuzaki, Tokio, Olmer, Merissa, Miyata, Kohei, Mokuda, Sho, Sakai, Daisuke, Masuda, Koichi, Asahara, Hiroshi, Lotz, Martin K.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156454/
https://ncbi.nlm.nih.gov/pubmed/29963746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12800
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