Wwp2 maintains cartilage homeostasis through regulation of Adamts5

The WW domain-containing protein 2 (Wwp2) gene, the host gene of miR-140, codes for the Wwp2 protein, which is an HECT-type E3 ubiquitin ligases abundantly expressed in articular cartilage. However, its function remains unclear. Here, we show that mice lacking Wwp2 and mice in which the Wwp2 E3 enzy...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Mokuda, Sho, Nakamichi, Ryo, Matsuzaki, Tokio, Ito, Yoshiaki, Sato, Tempei, Miyata, Kohei, Inui, Masafumi, Olmer, Merissa, Sugiyama, Eiji, Lotz, Martin, Asahara, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546747/
https://ncbi.nlm.nih.gov/pubmed/31160553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10177-1
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