Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

Osteoarthritis (OA), the most common aging-related joint disease, is caused by an imbalance between extracellular matrix synthesis and degradation. Here, we discover that both strands of microRNA-455 (miR-455), -5p and -3p, are up-regulated by Sox9, an essential transcription factor for cartilage di...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ito, Yoshiaki, Matsuzaki, Tokio, Ayabe, Fumiaki, Mokuda, Sho, Kurimoto, Ryota, Matsushima, Takahide, Tabata, Yusuke, Inotsume, Maiko, Tsutsumi, Hiroki, Liu, Lin, Shinohara, Masahiro, Tanaka, Yoko, Nakamichi, Ryo, Nishida, Keiichiro, Lotz, Martin K., Asahara, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260725/
https://ncbi.nlm.nih.gov/pubmed/34230481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24460-7
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