Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration

Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associatio...

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Veröffentlicht in:J Orthop Res
Hauptverfasser: Alvarez-Garcia, Oscar, Matsuzaki, Tokio, Olmer, Merissa, Masuda, Koichi, Lotz, Martin K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650945/
https://ncbi.nlm.nih.gov/pubmed/28430387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.23583
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