Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy

OBJECTIVE: Aging is a main risk factor for the development of osteoarthritis (OA) and the molecular mechanisms underlying the aging-related changes in articular cartilage include increased mammalian target of rapamycin (mTOR) signaling and defective autophagy. REDD1 is an endogenous inhibitor of mTO...

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Publicado no:Osteoarthritis Cartilage
Main Authors: Alvarez-Garcia, Oscar, Olmer, Merissa, Akagi, Ryuichiro, Akasaki, Yukio, Fisch, Kathleen M., Shen, Tao, Su, Andrew I., Lotz, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992644/
https://ncbi.nlm.nih.gov/pubmed/27118398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.04.015
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