Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

OBJECTIVES: Circadian rhythm (CR) was identified by RNA sequencing as the most dysregulated pathway in human osteoarthritis (OA) in articular cartilage. This study examined circadian rhythmicity in cultured chondrocytes and the role of the CR genes NR1D1 and BMAL1 in regulating chondrocyte functions...

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Detalhes bibliográficos
Publicado no:Osteoarthritis Cartilage
Main Authors: Akagi, Ryuichiro, Akatsu, Yorikazu, Fisch, Kathleen M., Alvarez-Garcia, Oscar, Teramura, Takeshi, Muramatsu, Yuta, Saito, Masahiko, Sasho, Takahisa, Su, Andrew I., Lotz, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438901/
https://ncbi.nlm.nih.gov/pubmed/27884645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2016.11.007
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