Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy

MicroRNAs (miRNAs) have been extensively examined in pathological cardiac hypertrophy. However, few studies focused on profiling the miRNA alterations in physiological hypertrophic hearts. In this study we generated a transgenic mouse model with cardiac-specific overexpression of miR-223. Our result...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Yang, Liwang, Li, Yutian, Wang, Xiaohong, Mu, Xingjiang, Qin, Dongze, Huang, Wei, Alshahrani, Saeed, Nieman, Michelle, Peng, Jiangtong, Essandoh, Kobina, Peng, Tianqing, Wang, Yigang, Lorenz, John, Soleimani, Manoocher, Zhao, Zhi-Qing, Fan, Guo-Chang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4957053/
https://ncbi.nlm.nih.gov/pubmed/27226563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.715805
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