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MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways

The initiation and development of diabetes are mainly ascribed to the loss of functional β-cells. Therapies designed to regenerate β-cells provide great potential for controlling glucose levels and thereby preventing the devastating complications associated with diabetes. This requires detailed know...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Yutian, Deng, Shan, Peng, Jiangtong, Wang, Xiaohong, Essandoh, Kobina, Mu, Xingjiang, Peng, Tianqing, Meng, Zhuo-Xian, Fan, Guo-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615686/
https://ncbi.nlm.nih.gov/pubmed/31118273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007755
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