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Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases
OBJECTIVES: A promising curative approach for HIV is to use designer endonucleases that bind and cleave specific target sequences within latent genomes, resulting in mutations that render the virus replication incompetent. We developed a mathematical model to describe the expression and activity of...
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| Publié dans: | J Antimicrob Chemother |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954920/ https://ncbi.nlm.nih.gov/pubmed/27090632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw104 |
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