Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases

OBJECTIVES: A promising curative approach for HIV is to use designer endonucleases that bind and cleave specific target sequences within latent genomes, resulting in mutations that render the virus replication incompetent. We developed a mathematical model to describe the expression and activity of...

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Bibliografische gegevens
Gepubliceerd in:J Antimicrob Chemother
Hoofdauteurs: Roychoudhury, Pavitra, De Silva Feelixge, Harshana S., Pietz, Harlan L., Stone, Daniel, Jerome, Keith R., Schiffer, Joshua T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2016
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954920/
https://ncbi.nlm.nih.gov/pubmed/27090632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw104
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