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Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir
BACKGROUND: RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies to date have focused on molecular clones with ideal target site recognition and...
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| Publié dans: | BMC Biol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6040082/ https://ncbi.nlm.nih.gov/pubmed/29996827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0544-1 |
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