AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Despite an existing effective vaccine, hepatitis B virus (HBV) remains a major public health concern. There are effective suppressive therapies for HBV, but they remain expensive and inaccessible to many, and not all patients respond well. Furthermore, HBV can persist as genomic covalently closed ci...

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Detalhes bibliográficos
Main Authors: Weber, Nicholas D., Stone, Daniel, Sedlak, Ruth Hall, De Silva Feelixge, Harshana S., Roychoudhury, Pavitra, Schiffer, Joshua T., Aubert, Martine, Jerome, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020843/
https://ncbi.nlm.nih.gov/pubmed/24827459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097579
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