AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication

Despite an existing effective vaccine, hepatitis B virus (HBV) remains a major public health concern. There are effective suppressive therapies for HBV, but they remain expensive and inaccessible to many, and not all patients respond well. Furthermore, HBV can persist as genomic covalently closed ci...

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Bibliografiske detaljer
Main Authors: Weber, Nicholas D., Stone, Daniel, Sedlak, Ruth Hall, De Silva Feelixge, Harshana S., Roychoudhury, Pavitra, Schiffer, Joshua T., Aubert, Martine, Jerome, Keith R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020843/
https://ncbi.nlm.nih.gov/pubmed/24827459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097579
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