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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
RAF kinases play a prominent role in cancer. Their mode of activation is complex, but critically requires dimerization of their kinase domains. Unexpectedly, several ATP-competitive RAF inhibitors were recently found to promote dimerization and transactivation of RAF kinases in a RAS-dependent manne...
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| Τόπος έκδοσης: | Nat Chem Biol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954776/ https://ncbi.nlm.nih.gov/pubmed/23685672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1257 |
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