Structures of closed and open conformations of dimeric human ATM

ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is...

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Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Adv
Hlavní autoři: Baretić, Domagoj, Pollard, Hannah K., Fisher, David I., Johnson, Christopher M., Santhanam, Balaji, Truman, Caroline M., Kouba, Tomas, Fersht, Alan R., Phillips, Christopher, Williams, Roger L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425235/
https://ncbi.nlm.nih.gov/pubmed/28508083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1700933
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