Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design

BACKGROUND: Quantifying tissue drug concentrations can yield important information during drug development, but complicates pharmacokinetic study design. Mucosal fluids collected by direct aspiration(cervicovaginal fluid; CVF) or swab(rectal fluid; RF) might be used as tissue concentration surrogate...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Cottrell, Mackenzie L., Prince, Heather M.A., Allmon, Andrew, Mollan, Katie R., Hudgens, Michael G., Sykes, Craig, White, Nicole, Malone, Stephanie, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Patterson, Kristine B., Kashuba, Angela D.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942408/
https://ncbi.nlm.nih.gov/pubmed/26999532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000996
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