Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis

Maraviroc-based regimens have been explored as preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). In this study, we utilized mucosal tissue drug exposure data, combined with target concentrations generated in vitro, in a pharmacokinetic-pharmacodynamic analysis to predict the...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Srinivas, Nithya, Cottrell, Mackenzie, Maffuid, Kaitlyn, Prince, Heather A., Nelson, Julie A. E., White, Nicole, Sykes, Craig, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Gonzalez, Daniel, Kashuba, Angela D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985753/
https://ncbi.nlm.nih.gov/pubmed/31740561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01729-19
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