A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine

Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylax...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Cottrell, Mackenzie L., Yang, Kuo H., Prince, Heather M. A., Sykes, Craig, White, Nicole, Malone, Stephanie, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Hudgens, Michael G., Wulff, Jacob, Patterson, Kristine B., Nelson, Julie A. E., Kashuba, Angela D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907409/
https://ncbi.nlm.nih.gov/pubmed/26917574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw077
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