Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine

The altered immune states of aging and HIV infection may affect intracellular metabolism of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC); increased cellular senescence decreases FTC-triphosphate (FTCtp) concentrations. The effects of age and inflammation on the ratio of intracellular...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Dumond, Julie B., Bay, Camden P., Nelson, Julie A. E., Davalos, Angel, Edmonds, Andrew, De Paris, Kristina, Sykes, Craig, Anastos, Kathryn, Sharma, Roopali, Kassaye, Seble, Tamraz, Bani, French, Audrey L., Gange, Stephen, Ofotokun, Ighovwerha, Fischl, Margaret A., Vance, David E., Adimora, Adaora A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449168/
https://ncbi.nlm.nih.gov/pubmed/32631821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00177-20
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