Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine

The altered immune states of aging and HIV infection may affect intracellular metabolism of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC); increased cellular senescence decreases FTC-triphosphate (FTCtp) concentrations. The effects of age and inflammation on the ratio of intracellular...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Dumond, Julie B., Bay, Camden P., Nelson, Julie A. E., Davalos, Angel, Edmonds, Andrew, De Paris, Kristina, Sykes, Craig, Anastos, Kathryn, Sharma, Roopali, Kassaye, Seble, Tamraz, Bani, French, Audrey L., Gange, Stephen, Ofotokun, Ighovwerha, Fischl, Margaret A., Vance, David E., Adimora, Adaora A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449168/
https://ncbi.nlm.nih.gov/pubmed/32631821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00177-20
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