Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis

Maraviroc-based regimens have been explored as preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV). In this study, we utilized mucosal tissue drug exposure data, combined with target concentrations generated in vitro, in a pharmacokinetic-pharmacodynamic analysis to predict the...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Srinivas, Nithya, Cottrell, Mackenzie, Maffuid, Kaitlyn, Prince, Heather A., Nelson, Julie A. E., White, Nicole, Sykes, Craig, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Gonzalez, Daniel, Kashuba, Angela D. M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6985753/
https://ncbi.nlm.nih.gov/pubmed/31740561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01729-19
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