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Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV Negative Men After Single and Multiple Dosing

OBJECTIVES: To describe first dose and steady-state pharmacokinetics (PK) of dolutegravir (DTG) in blood plasma (BP), seminal fluid (SF), colorectal tissue (RT), and rectal mucosal fluid (RF) of healthy HIV negative men. DESIGN: A Phase 1, open label, PK study that enrolled 12 healthy men taking DTG...

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書誌詳細
主要な著者: Greener, Benjamin N, Patterson, Kristine B, Prince, Heather MA, Sykes, Craig, Adams, Jessica L, Dumond, Julie B, Shaheen, Nicholas J, Madanick, Ryan D, Dellon, Evan S, Cohen, Myron S, Kashuba, Angela DM
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804901/
https://ncbi.nlm.nih.gov/pubmed/23945251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31829ed7a4
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