Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV Negative Men After Single and Multiple Dosing

OBJECTIVES: To describe first dose and steady-state pharmacokinetics (PK) of dolutegravir (DTG) in blood plasma (BP), seminal fluid (SF), colorectal tissue (RT), and rectal mucosal fluid (RF) of healthy HIV negative men. DESIGN: A Phase 1, open label, PK study that enrolled 12 healthy men taking DTG...

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Main Authors: Greener, Benjamin N, Patterson, Kristine B, Prince, Heather MA, Sykes, Craig, Adams, Jessica L, Dumond, Julie B, Shaheen, Nicholas J, Madanick, Ryan D, Dellon, Evan S, Cohen, Myron S, Kashuba, Angela DM
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804901/
https://ncbi.nlm.nih.gov/pubmed/23945251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31829ed7a4
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