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Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV Negative Men After Single and Multiple Dosing
OBJECTIVES: To describe first dose and steady-state pharmacokinetics (PK) of dolutegravir (DTG) in blood plasma (BP), seminal fluid (SF), colorectal tissue (RT), and rectal mucosal fluid (RF) of healthy HIV negative men. DESIGN: A Phase 1, open label, PK study that enrolled 12 healthy men taking DTG...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804901/ https://ncbi.nlm.nih.gov/pubmed/23945251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31829ed7a4 |
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