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Effect of HIV Infection and Menopause Status on Raltegravir Pharmacokinetics in the Blood and Genital Tract

BACKGROUND: This study describes first dose and steady state pharmacokinetics of raltegravir (RAL) in cervicovaginal fluid (CVF) and blood plasma (BP). METHODS: Three cohorts of women were enrolled sequentially in a single-site, open-label pharmacokinetic study of oral raltegravir 400 mg twice daily...

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Detalhes bibliográficos
Publicado no:Antivir Ther
Main Authors: Cottrell, Mackenzie L., Patterson, Kristine B., Prince, Heather M.A., Jones, Amanda, White, Nicole, Wang, Ruili, Kashuba, Angela D.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242325/
https://ncbi.nlm.nih.gov/pubmed/26040011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP2968
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