Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design

BACKGROUND: Quantifying tissue drug concentrations can yield important information during drug development, but complicates pharmacokinetic study design. Mucosal fluids collected by direct aspiration(cervicovaginal fluid; CVF) or swab(rectal fluid; RF) might be used as tissue concentration surrogate...

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Xehetasun bibliografikoak
Argitaratua izan da:J Acquir Immune Defic Syndr
Egile Nagusiak: Cottrell, Mackenzie L., Prince, Heather M.A., Allmon, Andrew, Mollan, Katie R., Hudgens, Michael G., Sykes, Craig, White, Nicole, Malone, Stephanie, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Patterson, Kristine B., Kashuba, Angela D.M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942408/
https://ncbi.nlm.nih.gov/pubmed/26999532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000996
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