Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design

BACKGROUND: Quantifying tissue drug concentrations can yield important information during drug development, but complicates pharmacokinetic study design. Mucosal fluids collected by direct aspiration(cervicovaginal fluid; CVF) or swab(rectal fluid; RF) might be used as tissue concentration surrogate...

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Detaylı Bibliyografya
Yayımlandı:J Acquir Immune Defic Syndr
Asıl Yazarlar: Cottrell, Mackenzie L., Prince, Heather M.A., Allmon, Andrew, Mollan, Katie R., Hudgens, Michael G., Sykes, Craig, White, Nicole, Malone, Stephanie, Dellon, Evan S., Madanick, Ryan D., Shaheen, Nicholas J., Patterson, Kristine B., Kashuba, Angela D.M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942408/
https://ncbi.nlm.nih.gov/pubmed/26999532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000996
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