Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of retroviruses and activate ubiquitin-dependent antiviral responses upo...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wagner, Jonathan M, Roganowicz, Marcin D, Skorupka, Katarzyna, Alam, Steven L, Christensen, Devin, Doss, Ginna, Wan, Yueping, Frank, Gabriel A, Ganser-Pornillos, Barbie K, Sundquist, Wesley I, Pornillos, Owen
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936894/
https://ncbi.nlm.nih.gov/pubmed/27253059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16309
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