Hexagonal assembly of a restricting TRIM5α protein

TRIM5α proteins are restriction factors that protect mammalian cells from retroviral infections by binding incoming viral capsids, accelerating their dissociation, and preventing reverse transcription of the viral genome. Individual TRIM5 isoforms can often protect cells against a broad range of ret...

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Autors principals: Ganser-Pornillos, Barbie K., Chandrasekaran, Viswanathan, Pornillos, Owen, Sodroski, Joseph G., Sundquist, Wesley I., Yeager, Mark
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021009/
https://ncbi.nlm.nih.gov/pubmed/21187419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013426108
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