Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

TRIM5α is a restriction factor that senses incoming retrovirus cores through an unprecedented mechanism of nonself recognition. TRIM5α assembles a hexagonal lattice that avidly binds the capsid shell, which surrounds and protects the virus core. The extent to which the TRIM lattice can cover the cap...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Skorupka, Katarzyna A., Roganowicz, Marcin D., Christensen, Devin E., Wan, Yueping, Pornillos, Owen, Ganser-Pornillos, Barbie K.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881174/
https://ncbi.nlm.nih.gov/pubmed/31807695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw3631
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