Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation

Deregulated cellular metabolism is a hallmark of tumors. Cancer cells increase glucose and glutamine flux to provide energy needs and macromolecular synthesis demands. Several studies have been focused on the importance of glycolysis and pentose phosphate pathway. However, a neglected but very impor...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Lucena, Miguel C., Carvalho-Cruz, Patricia, Donadio, Joana L., Oliveira, Isadora A., de Queiroz, Rafaela M., Marinho-Carvalho, Monica M., Sola-Penna, Mauro, de Paula, Iron F., Gondim, Katia C., McComb, Mark E., Costello, Catherine E., Whelan, Stephen A., Todeschini, Adriane R., Dias, Wagner B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933211/
https://ncbi.nlm.nih.gov/pubmed/27129262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729236
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