Evidence of Ternary Complex Formation in Trypanosoma cruzi trans-Sialidase Catalysis

Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chagas disease chemotherapy. In this study, we investigated the implications of active site flexibility on the biochemical mechanism of TcTS. Molecular dynamics studies revealed remarkable plasticity in the TcTS catalytic site, dem...

Full description

Saved in:
Bibliographic Details
Main Authors: Oliveira, Isadora A., Gonçalves, Arlan S., Neves, Jorge L., von Itzstein, Mark, Todeschini, Adriane R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879565/
https://ncbi.nlm.nih.gov/pubmed/24194520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399303
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items