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Evidence of Ternary Complex Formation in Trypanosoma cruzi trans-Sialidase Catalysis
Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chagas disease chemotherapy. In this study, we investigated the implications of active site flexibility on the biochemical mechanism of TcTS. Molecular dynamics studies revealed remarkable plasticity in the TcTS catalytic site, dem...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3879565/ https://ncbi.nlm.nih.gov/pubmed/24194520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399303 |
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