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Evidence of Ternary Complex Formation in Trypanosoma cruzi trans-Sialidase Catalysis

Trypanosoma cruzi trans-sialidase (TcTS) is a key target protein for Chagas disease chemotherapy. In this study, we investigated the implications of active site flexibility on the biochemical mechanism of TcTS. Molecular dynamics studies revealed remarkable plasticity in the TcTS catalytic site, dem...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Oliveira, Isadora A., Gonçalves, Arlan S., Neves, Jorge L., von Itzstein, Mark, Todeschini, Adriane R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879565/
https://ncbi.nlm.nih.gov/pubmed/24194520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.399303
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